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Gaikwad,., Agrawal-Rajput,., 2015.
Supplementary materials Supplementary material associated with this article can be found, in the online version, at doi:ymed.2016.03.013.Rathee,., Thanki,., Bhuva,., Anandjiwala,., Agrawal,., 2013.In this regard, berberine has been explored for its possible benefits against neuroblastoma.Of three independent experiments.Von Mering,., Fluynen,., Jaeggi,., Schmidt,., Bork,., houten kastje met slot Snel,., 2003.For the experiments, cells were washed twice and treated with berberine in 5 FBS containing dmem for indicated time and dose.Berberine treatment reverts the expression of EMT markers a result of decreased TGF-beta.Targeting DNA topoisomerase II in cancer chemotherapy.In the present study, using the N2a neuroblastoma cells we aimed to (i) determine the potential of berberine for neuronal differentiation and inhibition of cancer sternness in NB, (ii) determine how berberine regulates cancer-sternness at PI3/AKT and Ras-Raf-ERK and p38 mapk signalling, and (iii) determine.TGF-beta induced EMT proceeds through activation of PI3K-AKT and RAS-RAF-MEK-ERK mapk signalling cascade; represents a critical target.Expression of apoptotic, bak and bax increased in a dose-dependent manner while the expression of anti-apoptotic genes, bcl2 and bcl-xl was decreased (Fig.




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